INNOVATIVE BIOPHYSICAL TECHNOLOGIES

A. DERMATOLOGY RESEARCH ACHIEVEMENTS - Stanford University Medical School


PSORIASIS RESEARCH


  • Developed method for long-term maintainance of  human skin mast cells in tissue culture


  • Demonstrated effects of neuropeptides on human skin mast cells


  • First time characterization of the  sodium-hydrogen antiporter in human keratinocytes


  • Developed new psycho-neuroimmunology  model explaining effects of mental & emotional states on skin physiology


B. SKIN BIOLOGY RESEARCH - Estee Lauder R&D


I. ESSENTIAL OILS


  • First time characterization of physiological effects of topical essential oils on human skin

                                 Anti-oxidant

                                 Anti-inflammatory

                                 Modulatory effects on specific biochemical pathways


  • First time characterization of sensory effects of topical essential oils on human skin

                                 Heating

                                  Cooling

                                  Tingling


  • Clinical evaluation of essential oils blends to affect novel mental and emotional states of consciousness

                                  Trustworthiness

                                  Happiness

                                  Sociability

                              

  • Developed novel platform for formulators describing physiological and psychological effects of essential oils


II. ELECTROMAGNETIC FIELDS


      a. CLINICAL


  • Measured endogenous DC electric fields in normal and wrinkled skin


  • First time characterization of the effects of external DC electric fields on wrinkles

  •  Measured the pulsed electromagnetic fields emitted by human skin


  • Developed new biophysical method for measuring charge distribution on skin surface


  • Characterized the effects of topical cosmetic products on charge distribution on skin surface

 

    b. IN-VITRO


  • Investigated the effects of external electromagnetic fields on human keratinocytes


  • Characterized the effects of visible light on biochemical pathways in human keratinocytes

                                                anti-oxidant activity

                                                anti-inflammatory role of interleukins    

                                                melatonin                


C. MODELLING


  • Co-developed a comprehensive model of skin aging based on a micro- inflammatory cycle


  • Published the model in 2001


  • Invited to update and republished the model in 2012